NFL Today: Kansas City Chiefs Head to São Paulo for Historic Season Opener
The NFL’s regular season continues its international expansion tonight, Friday, September 5, 2025, with the Kansas City Chiefs traveling to face the Los Angeles Chargers in the NFL São Paulo Game. Kickoff is set for 8:00 PM Eastern, exclusively on YouTube, at the Neo Química Arena in São Paulo, Brazil.
This marks the second regular-season contest held outside the United States since London’s games in 2023 and represents the league’s commitment to growing its global footprint. The Chiefs enter with a slight 3.5-point spread in their favor, while the over/under is set at 46.5 points.
Tonight’s matchup will feature the reigning AFC champions in a challenging road environment, as they aim to build on their season-opening victory, while Los Angeles looks to leverage home-style advantage-even far from home turf.
No final score is yet available; full real-time updates, box scores, and highlights will be provided throughout the evening.
Sources: ESPN Schedule
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